Oxygen intermediates on endogenous uveitis

Immunoglobulins in endogenous uveitis.

Examination of 300 patients suffering from endogenous uveitis revealed raised levels of IgG in 24 per cent, IgA in 17 per cent, and IgM in 10 per cent. A raised level of one or more immunoglobulins was found more frequently in anterior uveitis than in the posterior form (44 compared with 24 per cent), in bilateral cases (47 compared with 35 per cent), and in relation to certain general diseases...

Macrophage oxygen-dependent antimicrobial activity. IV. Role of endogenous scavengers of oxygen intermediates

The activities of the endogenous O2- and H2O2 scavenging enzymes, superoxide dismutase (SOD), glutathionine peroxidase (GP), and catalase, were measured in lysates of the intracellular parasite, Toxoplasma gondii, and in various macrophage populations. During 72 h of cultivation in standard medium alone, the catalase activity of in vivo-activated toxoplasma-immune macrophages (IM) and immune-bo...

SnapShot: Reactive Oxygen Intermediates (ROI)

II . The Role of Oxygen Intermediates

In the accompanying report (1), we demonstrated that Toxoplasma gondii, an obligate intracellular parasite, is susceptible to oxygen intermediates generated by the xanthine oxidase system. The present study examines the contribution of oxidative metabolites to macrophage killing and inhibition of growth of intracellular T. gondii. Our observations indicate that an oxygen-dependent antimicrobial...

Immunosuppressive treatment of choroidal neovascularization associated with endogenous posterior uveitis.

OBJECTIVE To determine whether resolution of choroidal neovascularization (CNV), a recognized sight-threatening complication of endogenous posterior uveitis, and maintenance of vision could be achieved with immunosuppression. PATIENTS AND METHODS Fourteen patients (17 eyes) with CNV associated with endogenous posterior uveitis were enrolled in an open study. Ages ranged from 5 to 51 years. Th...